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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
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Frequently Asked Questions

Q. Cialis can increase blood pressure?

Cialis is not suitable for everyone.

q. What is the dosage of cialis?

Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

Common side effects reported from Cialis use include:

  • Headache
  • Indigestion
  • Heartburn
  • Upset stomach
  • Gas
  • Nausea
  • Flushing

More severe side effects include:

  • Painful erections or erections that last longer than 4 hours
  • Sudden loss of vision
  • Sudden loss of hearing
  • Ringing in the ears
  • Chest pain
  • Shortness of breath
  • Painful urination
  • Increased urination frequency
  • Fainting
  • Dizziness
  • Skin rash
  • Hives
  • Facial swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.

Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

azithromycin (Zithromax) is a prescription medication for Cialis. Cialis can cause potentially serious adverse reactions if you:
  • Had a heart attack or stroke within the last 6 months
  • Have liver or kidney problems
  • Gets up your blood pressure ( hypotension) by taking more than the recommended dose
  • Take nitrates for chest pain
  • Take guanylate cyclase stimulators for high blood pressure
  • Consider using [arginine] or other providers of a blood-clot system

As with prescription medications, let your doctor know if you have any of the following conditions:

  • A blood cell disorder (eg, anemia)
  • Liver or kidney disease
  • New or worsening heart problems or a blood cell disorder (eg, anemia)
  • Alcohol dependency
  • Active blood clots (eg, leukemia, multiple myeloma)
  • Protein C deficiency
  • Stomach ulcers or bleeding problems
  • Severe hypertension

As with all prescription medications, let your doctor know if you have any of the above conditions. Cialis can interact with these medications:

  • Riociguat
  • other antibiotics
  • St. John’s wort
  • Other medications that lower blood pressure
  • Xopenin
  • Some HIV protease inhibitors
  • Some blood pressure medication
  • Other medications for acute pain

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Cialis 5 mg 28 tablets

Cialis 5 mg 28 tablets contains the active substance Tadalafil. It is used to treat erectile dysfunction (ED) in men. ED is a sexual condition in which an individual or a loved one experiences difficulty in achieving an erection or maintaining an erection for sexual activity. This problem can be caused by certain health conditions, such as diabetes, hypertension, or heart diseases. Cialis 5 mg 28 tablets should be taken as advised by a doctor. The usual dosage is one tablet approximately one hour before sexual activity. However, if this amount of tablet is very heavy, you might take it as many times as needed to achieve an effective response. Do not take more than one tablet daily, even if you find that you will be taking them for different times.

Cialis 5 mg 28 tablets: How to take?

Take the tablet as advised by your doctor. The recommended dose is one tablet about one hour before sexual activity. Take the medicine in the same way as you take in breakfast, but with a meal. Take the tablet about one hour before planned sexual activity. However, it is better to take it at a fixed time. The full recommended dosing schedule is as per your doctor's instructions. Do not take extra medicine to make up for the regular dose.

To get the best benefit from Cialis 5 mg 28 tablets, it is better to take it at the same time every day. Drink a full glass of water when taking Cialis 5 mg 28 tablets. Cialis 5 mg 28 tablets can be taken with or without food. The tablets should be swallowed whole with a glass of water. Do not take more than one tablet a day unless your doctor tells you to.

You can take Cialis 5 mg 28 tablets with or without food. Do not take more than one tablet daily. Do not stop taking the medication without consulting your doctor. Taking too much Cialis 5 mg 28 tablets can cause harmful effects and trouble. Inform your doctor if you have any history of cardiovascular diseases, liver disease, kidney disease, or heart problems. The tablets should not be used in combination with any other medications that contain nitrates (e.g., nitroglycerin, isocarboxazid, pemoline nitrate). Before taking Cialis 5 mg 28 tablets, inform your doctor if you are allergic to it, have hypertension, history of heart attack, liver or kidney problems, grapefruit or grapefruit juice allergy, heart problems, diabetes, or any other medical condition. Taking Cialis 5 mg 28 tablets with some other medicines might lead to unwanted side effects such as chest pain, fast or irregular heartbeat, or nausea. Inform your doctor if you are pregnant or breastfeeding. Cialis 5 mg 28 tablets should not be used in children. It is better to take this medicine as instructed by your doctor.

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